Detalhe da pesquisa
1.
Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling.
Nature
; 623(7988): 745-751, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37788684
2.
Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.
J Am Chem Soc
; 144(38): 17709-17720, 2022 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36106767
3.
Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.
J Org Chem
; 86(2): 1730-1747, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356273
4.
RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation.
J Immunol
; 202(1): 79-92, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30478092
5.
Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity.
J Am Chem Soc
; 142(6): 3094-3103, 2020 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31927959
6.
Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists.
Bioorg Med Chem Lett
; 30(19): 127466, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32763309
7.
Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.
Bioorg Med Chem Lett
; 30(17): 127392, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738966
8.
Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Bioorg Med Chem Lett
; 30(23): 127521, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882417
9.
Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light.
J Org Chem
; 84(13): 8360-8379, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30905152
10.
Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides.
J Org Chem
; 83(5): 3000-3012, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420898
11.
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg Med Chem Lett
; 28(2): 85-93, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29233651
12.
Correction: RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation.
J Immunol
; 206(11): 2764-2765, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980584
13.
Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 27(4): 855-861, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28108251
14.
Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 26(17): 4256-60, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476421
15.
Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.
Angew Chem Int Ed Engl
; 55(2): 785-9, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611496
16.
Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research.
J Med Chem
; 67(3): 1701-1733, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38290426
17.
Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core.
Bioorg Med Chem Lett
; 23(20): 5571-4, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24011644
18.
Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.
Bioorg Med Chem Lett
; 23(19): 5448-51, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916594
19.
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 23(19): 5442-7, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23953070
20.
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Bioorg Med Chem Lett
; 23(14): 4120-6, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746475